Here’s the patent that technically led to Endothil CR first, followed by Stemulite, a far more potent formulation using the same principles.
Development of muscle mass in a mammal
US Patent Issued on July 11, 2006
Inventor(s): David P. Summers, James Davidson
Assignee: Nutraceutical Development Corporation
Application: No. 10633325 filed on 2003-08-02
Claims
The invention claimed is:
1. A method of developing muscle mass in a mammal by stimulating, recruiting and mobilizing muscle cells to a specific muscle mass, the method comprising administering nicotine or nicotine acetylcholine receptor agonist (nAChR) to a mammal in an amount sufficient combined with exercise to increase said specific muscle mass.
2. The method of claim 1 wherein the muscle cells are differentiated from endogenous stem cells.
3. The method of claim 1 wherein said muscle cells are recruited to said specific muscle mass in response to said exercise of said specific muscle mass.
4. The method of claim 3 wherein said exercise stimulates the muscle cells of said specific muscle mass to express nicotinic acetylcholine receptors.
5. The method of claim 4 including the step of administering nicotine or a nAChR agonist to bind said nicotinic acetylcholine receptors.
6. The method of claim 5 wherein said binding stimulates the release of growth factors, including human growth hormone (HGH), vascular endothelial growth factor (VEGF), basic fibroblast growth factors (bFGF) and other chemokines, cytokines and attractants to stem cell recruitment, migration and mobilization at said specific muscle mass.
7. The method of claim 2 wherein said stem cells differentiate into the phenotype of said specific muscle mass.
8. The method of claim 3 wherein said exercise stimulates said specific muscle mass to release metabolites, catecholamines, cytokines, chemokines, and/or cause an inflammatory response in said specific muscle mass.
9. The method of claim 1 wherein the nicotine or nicotine acetylcholine receptor agonist (nAChR) is administered in an amount sufficient to produce increased thermogenesis.
Other References
- M. Korbling, et al. Adult stem cells for tissue repair-a new therapeutic concept?; NEJM, Aug. 7, 2003, vol. 349, Iss. 6, pp. 570-587
- Caterson et al., Application of Mesenchymal Stem Cells in Regeneration of Musculoskeletal Tissues, Feb. 5, 2001, Medscape General Medicine, 3(1), 2001
- Murphy, Kicking butts:Forget for a moment all that stuff about cancer – that’s tomorrow. Smoking can screw up your workout today!, Men’s Fitness, Nov. 2002
- Hawke, Muscle Stem Cells and Exercise Training, Exerc. Sport Sci Rev. 2005; 33 (2): 63-68
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