The Discovery of Stemulite Came from This Study …


Nothing personal, but this abstract is probably over your head.

You see, Stemulite isn’t just a bunch of random ingredients thrown together as some ignorant (and I mean that in the non-pejorative sense - kinda’) people have suggested in certain forums.

Sure, you can buy SerraPeptase, indium, ALA, etc. from different sources.

But you’ll be missing the most potent ingredient - the proprietary eggplant extract that gets your own adult stem cells to actually create new muscle cells. Not just puff up existing cells that way steroids do.

That’s the difference!

Basically, if you don’t understand anything about the study below and the importance of nicotinic acetylcholine receptors (nAChR), you don’t truly understand the science behind Stemulite.

(So stop putting it down in forums if you haven’t tried it or even bother to learn the science behind it first. Yep, you know who you are.)

Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice.

Am J Pathol. 2002 Jul;161(1):97-104. Jacobi J, Jang JJ, Sundram U, Dayoub H, Fajardo LF, Cooke JP.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Recently, we have discovered an endogenous cholinergic pathway for angiogenesis mediated by endothelial nicotinic acetylcholine receptors (nAChRs). Since angiogenesis plays a major role in wound repair, we hypothesized that activation of nAChRs with nicotine would accelerate wound healing in a murine excisional wound model.

In genetically diabetic and control mice full-thickness skin wounds (0.8 cm) were created on the dorsum and topically treated over 7 days with either vehicle (phosphate-buffered saline, PBS) or nicotine (10(-8) mol/L, 10(-9) mol/L; each, n = 5).

Wound size was measured over 14 days followed by resection, histological analysis, and quantitation of vascularity. In diabetic animals an agonist (epibatidine, 10(-10) mol/L) or antagonist (hexamethonium, 10(-4) mol/L) of nAChRs as well as the positive control basic fibroblast growth factor (bFGF, 25 microg/kg) were also tested.

To further study the role of endothelial nAChRs in angiogenesis, we used an ex vivo vascular explant model.

In diabetic mice wound healing was markedly impaired. Nicotine significantly accelerated wound healing as assessed by closure rate and histological score.

The effects of nicotine were equal to bFGF and were mimicked by epibatidine and blocked by hexamethonium. Histomorphometry revealed increased neovascularization in animals treated with nicotine.

Furthermore, capillary-like sprouting from vascular explants was significantly enhanced by nicotine.

In conclusion, agonist-induced stimulation of nAChRs accelerates wound healing in diabetic mice by promoting angiogenesis. We have discovered a cholinergic pathway for angiogenesis that is involved in wound healing, and which is a potential target for therapeutic angiogenesis.

Allow me to show off my fancy Duke degree and help with the translation…

The introduction of nicotine, obviously an extract of tobacco, a plant in the Solanaceae family, led to angiogenesis - the growth of new blood vessels from pre-existing vessels.

This growth of new blood vessels led Dr. Summers to ask, “What happens if we use nicotine [or a nicotine-like substance] with micro-damaged human muscle?”

Keep in mind, this study was way back in 2002. Dr. Summers’ later discovered other plants in the Solanaceae family - such as tomato extract (as in Endothil CR) and eggplant extract (as in Stemulite) produced the same effect of getting adult stem cells to generate new cells.

Thus, Endothil CR. Then Stemulite, a more powerful stem cell agonist based on the same clinical studies.

So don’t be fooled by what looks like simple ingredients like Tomato Extract in Endothil and Eggplant Extract in Stemulite and think, “This must be a scam.” You simply need to learn a little more biochemistry :-)

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